天疱疮

Pemphigus is a disease that causes blistering of the skin and the inside of the mouth, nose, throat, eyes, and genitals. The disease is rare in the United States. Pemphigus is an autoimmune disease in which the immune system mistakenly attacks cells in the top layer of the skin (epidermis) and the mucous membranes. People with the disease produce antibodies against desmogleins, proteins that bind skin cells to one another, and less commonly other proteins in the skin. When these bonds are disrupted, skin becomes fragile, and fluid can collect between its layers, forming blisters. There are several types of pemphigus, but the two main ones are: Pemphigus vulgaris, which normally affects the mucous membranes, such as the inside of the mouth, and can also affect the skin. Pemphigus foliaceus, which only affects the skin. There is no cure for pemphigus, but in many cases, it is controllable with medications.